From 1896 to 1903, Mayo was an actress on the stage, after which she turned to playwriting and became very successful at it. In 1917, she was a founding member of the Goldwyn Company (later part of MGM) and her play Polly of the Circus became its first film. She went on to adapt many of her plays to the silent screen. Her other works include Baby Mine (1910), Twin Beds (1914), Trouping for the Troops (1919), Seeing Things (1920)and Cyprienne (1941).
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